International Registry and Biorepository for TMA(Thrombotic Microangiopathy)

Terminated

• Conditions: Thrombotic Microangiopathy; Thrombotic Thrombocytopenic Purpura; Hemolytic Uremic Syndrome

• Registration Number: NCT00593229
• Lead Sponsor: Northwell Health

Brief Summary

This registry will collect clinical data and store biosamples (seru, plasma, urine, and DNA) annually from pediatric patients with thrombotic mcroangiopathy

Detailed Description

Children age, 6 months - 18 years, are eligible if they have one of the following categories of thrombotic microangiopathy (TMA):(1) severe D+HUS; (2) non-familial atypical HUS; (3) familial atypical HUS; or (4) TTP

Patients are seen intially and annually thereafter

Biosamples are collected for storage annually.

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2008-01-02
• Study First Submitted QC: 2008-01-11
• Study First Posted: 2008-01-14
• Primary Completion: 2011-10
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-18
• Last Update Posted: 2013-06-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Severe HUS, familial or non-familial atypical HUS, TTP

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine genetic causes of TMA	Ongoing
Determine epidemiology and outcomes of the various forms of TMA	Ongoing

Secondary Outcome Measures

Name	Time	Method
Initiate clinical trials in TMA	In the future

Trial Locations

Locations (1)

Schneider Chldren's Hospital; 🇺🇸 New Hyde Park, New York, United States