Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted Self-administration of Ethanol (CASE)
Completed
- Conditions
- Alcoholism
- Registration Number
- NCT01063166
- Lead Sponsor
- Technische Universität Dresden
- Brief Summary
The Computer-Assisted Self-administration of Ethanol (CASE)will be administered twice, at the ages 18 and 20, in a prospective study of 80 adolescents living in the Dresden area. The sample will be recruited for a differential family history of alcoholism (FHA) and gender, with inventories of alcohol use disorder (AUD) symptoms and personal recent drinking history (RDH) obtained prior to each CASE session.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
Inclusion Criteria
- (a) male and female Caucasian volunteers aged 18 years/0 months to 19 years/11 months;
- (b) written informed consent by the subject;
- (c) habitual social drinking during the two months preceding participation, defined by at least one drinking day in any two weeks-interval;
- (d) at least one prior experience of alcohol intoxication
- (e) being able to abstain from tobacco use for four hours without developing nicotine withdrawal symptoms;
- (f) effective contraception in female participants;
- (g) consenting to abstain from any illegal substance use for 2 weeks prior to participation;
- (h) living within 15 km (9.5 miles) from downtown Dresden;
- (i) sufficient information concerning alcohol use in both parents and in at least four second-degree relatives
Exclusion Criteria
- (a) prior medical treatment due to alcohol use;
- (b) current or prior history of any serious disease, including CNS, cardiovascular, respiratory, gastrointestinal, hepatic, renal, endocrine, alcohol or drug dependence, but not alcohol abuse;
- (c) current history of Axis-I psychiatric illness, including premenstrual dysphoric disorder;
- (d) current or prior history of alcohol-induced flushing reactions;
- (e) positive urine screen for cannabinoids, cocaine, amphetamines, opiates, or benzodiazepines;
- (f) light or non-drinkers: averaging less than 2 standard drinks per week in the preceding two months;
- (g) intention to become pregnant
- (h) pregnancy or positive urine pregnancy screening or breast-feeding;
- (i) any alcohol intake on the test day or the day before;
- (k) use of medications known to interact with alcohol within 2 weeks of the study;
- (l) positive hepatitis or HIV at screening, provided the subject consented to these tests
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Alcohol consumption 2 years Alcohol consumption, as measured by a Timeline Followback Interview and experimental Self-Administration.
- Secondary Outcome Measures
Name Time Method Alcohol Use Disorders 2 years
Trial Locations
- Locations (1)
Universitaetsklinikum Carl Gustav Carus at the Technische Universitaet Dresden
🇩🇪Dresden, Saxony, Germany