Circulating Epigenetics in Pancreatic Surgery

• Conditions: Pancreatic Neoplasms
• Interventions: Diagnostic Test: Blood sampling

• Registration Number: NCT04947696
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The overall objective of the study is to assess DNA-methylation changes in circulating blood cells and cell free DNA in plasma from patients undergoing the Whipples procedure for pancreatic caner

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-06
• Study First Submitted: 2021-06-24
• Study First Submitted QC: 2021-06-24
• Last Update Submitted: 2021-06-24
• Study First Posted: 2021-07-01
• Last Update Posted: 2021-07-01
• Study Start: 2021-07-30
• Primary Completion: 2022-07-01
• Study Completion: 2023-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients with pancreatic cancer scheduled for the Whipples procedure

Exclusion Criteria

• Under 18 years of age
• Pregnancy
• Unable to provide informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Blood sampling	Patients undergoing a Whipples procedure for pancreatic cancer

Primary Outcome Measures

Name	Time	Method
Changes in DNA-methylation patterns from the pre to postoperative setting	Up to 30 days postoperatively

Secondary Outcome Measures

Name	Time	Method
Occurence of a postoperative complication	30 days postoperatively
Relapse of pancreatic cancer	2 years from time of operation

Trial Locations

Locations (1)

Rigshospitalet; 🇩🇰 Copenhagen, Denmark