JPRN-jRCTs031180131已完成未知
Effect of adenosine 2a antagonist on striatal dopamine D2 receptors - STA2AD2 study
Okita Kyoji0 个研究点目标入组 36 人开始时间: 2019年2月18日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 36
研究概览
简要总结
This is a double-blind, randomized controlled trials aiming to evaluate the effect of instradefylline, a selective adenosine 2A receotor antagonist, compared to placebo on dopamine D2 receptor availability in striatum. The pharmacological intervention was 2 week, and positron emission tomography (PET) scan with 11C-raclopride was performed before and after the intervention. The result shows that istradefylline, compared placebo, increase the striatal D2 receptor availability.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 <= 65age old（—）
- 性别
- Male
入选标准
- •1.Physically and mentally healthy male nonsmokers aged between 20 and 65 (nonsmoker is defined as those who has not smoked for the last one year)
- •2.No problems with communication in Japanese language and understanding documents of informed consent
排除标准
- •1.Past history of neurological and/or psychiatric disorders
- •2.Intracranial lesion(s) seen in MRI
- •3.Impairment of liver and/or renal function
- •4.HIV seropositive
- •5.Positive urine-sample test for illegal drug
- •6.Past history of suicidal ideation or attempt
- •7.Claustrophobia or aichmophobia
- •8.MRI imcompatible metals inside the body
- •9.Use of psychotropic drugs which could have an impact on dopamine D2 receptor availability
- •10.Engaged in night work
- •11.Employees of National Center of Neurology and Psychiatry or any companies that have a business connection with National Center of Neurology and Psychiatry
- •12.Participate in any other clinical trials or studies
- •13.In case of principle investigator judges inappropriate to participate in the study
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