Effect of adenosine 2a antagonist on striatal dopamine D2 receptors - STA2AD2 study

Okita Kyoji0 个研究点目标入组 36 人开始时间: 2019年2月18日最近更新: 2023年10月17日

适应症

试验速览

阶段: 未知
状态: 已完成
发起方
入组人数: 36

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

This is a double-blind, randomized controlled trials aiming to evaluate the effect of instradefylline, a selective adenosine 2A receotor antagonist, compared to placebo on dopamine D2 receptor availability in striatum. The pharmacological intervention was 2 week, and positron emission tomography (PET) scan with 11C-raclopride was performed before and after the intervention. The result shows that istradefylline, compared placebo, increase the striatal D2 receptor availability.

研究设计

研究类型: Interventional

入排标准

年龄范围: >= 20age old 至 <= 65age old（—）
性别: Male

入选标准

•1.Physically and mentally healthy male nonsmokers aged between 20 and 65 (nonsmoker is defined as those who has not smoked for the last one year)
•2.No problems with communication in Japanese language and understanding documents of informed consent

排除标准

•1.Past history of neurological and/or psychiatric disorders
•2.Intracranial lesion(s) seen in MRI
•3.Impairment of liver and/or renal function
•4.HIV seropositive
•5.Positive urine-sample test for illegal drug
•6.Past history of suicidal ideation or attempt
•7.Claustrophobia or aichmophobia
•8.MRI imcompatible metals inside the body
•9.Use of psychotropic drugs which could have an impact on dopamine D2 receptor availability
•10.Engaged in night work
•11.Employees of National Center of Neurology and Psychiatry or any companies that have a business connection with National Center of Neurology and Psychiatry
•12.Participate in any other clinical trials or studies
•13.In case of principle investigator judges inappropriate to participate in the study

研究者

发起方

Okita Kyoji

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