Effect of adenosine 2a antagonist on striatal dopamine D2 receptors in subjects with methamphetamine use disorder: A PET study aiming novel pharmacotherapy development - A2D2-S

Okita Kyoji0 个研究点目标入组 30 人开始时间: 2021年1月28日最近更新: 2023年10月17日

试验速览

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•1)Subject with methamphetamine dependence meeting with DSM-IV-TR criteria aged between 20 and 65
•2)Subjects who have used any stimulant within one year
•3)Having no difficulties in understanding/talking in Japanese

•1)Past history of neurological and/or psychiatric disorders or current possibility of these disorders
•2)Meeting a criteria of dependence on any substance other than methamphetamine or nicotine
•3)Regular use of psychotropic drugs which could have an impact on dopamine D2 receptor availability
•4)Use of drugs having effects of CYP3A inhibition or induction
•5)Intracranial lesion(s) seen in MRI
•6)Positive urine-sample test for illegal drug
•7)Past history of suicidal ideation or attempt
•8)Claustrophobia or aichmophobia
•9)Use of psychotropic drugs which could have an impact on dopamine D2 receptor availability
•10)Participate in any other clinical trials or studies
•11)In case of principle investigator judges inappro priate to participate in the study

发起方

Okita Kyoji