跳至主要内容
临床试验/NCT06290154
NCT06290154招募中不适用

Factors Associated With Short-Term Major Adverse Cardiovascular Events After Liver Transplantation

Sun Yat-sen University2 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2024年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
200
试验地点
2
主要终点
a composite outcome of new cardiovascular disease after liver transplantation

研究概览

简要总结

Cardiovascular disease has become the leading cause of death early after liver transplantation (LT). The aging LT population is accompanied with the increasing prevalence of cardiovascular risk factors such as hypertension, diabetes, and hyperlipidemia. Furthermore, cirrhosis has been known to cause alterations in the systemic haemodynamic system and cardiac muscle dysfunction, systolic and/or diastolic, known as Cirrhotic cardiomyopathy (CCM). Hence, transthoracic echocardiography is required in all LT candidates for preprocedural evaluation and risk stratification. However, traditional echocardiographic indices of cardiac function have low sensitivity. It is unclear whether comprehensive echocardiographic multiparameters, including speckle tracking echocardiograph (STE) and tissue doppler imaging (TDI) can help improve preoperative risk stratification. Therefore, we sought to analyze the ability of clinical and comprehensive echocardiography variables to predict intraoperative and perioperative cardiac events and cardiac mortality in our LT patient experience up to early post-liver transplant.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age > 18 years,
  • End-stage cirrhosis patients who will receive liver transplantation,
  • Patients voluntarily take part in the study and write informed consent.

排除标准

  • Decreased left ventricular systolic function (ejection fraction <45%),
  • Significant uncorrectable structural cardiac abnormalities (eg, symptomatic coronary heart disease, advanced cardiomyopathy, severe valvular disease, severe congenital heart disease, etc),
  • Uncontrolled pulmonary hypertension defined as pulmonary arterial systolic pressure ≧ 35mm Hg at rest despite maximal medical management,
  • Circulatory or respiratory system with a score of 4 based on the preoperative Organ Dysfunction (CLIF-SOFA) score,
  • Second-time liver transplantation,
  • Combined organ transplantation,
  • Satisfactory quality echocardiography could not be obtained before operation.

结局指标

主要结局

a composite outcome of new cardiovascular disease after liver transplantation

时间窗: 3 months after liver transplantation

new symptomatic CAD, new heart failure (systolic and/or diastolic), new arrhythmia (atrial and/or ventricular), and/or new cardiac arrest, or cardiac death.

次要结局

未报告次要终点

研究者

发起方
Sun Yat-sen University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jia Liu

Dr

Sun Yat-sen University

研究点 (2)

Loading locations...

相似试验

Factors Associated With Posttransplant Cardiac... | 临床试验