Transcranial Random Noise Stimulation in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients
Overview
- Phase
- Not Applicable
- Intervention
- Transcranial Random Noise Stimulation
- Conditions
- Substance Use Disorder
- Sponsor
- Spanish Foundation for Neurometrics Development
- Enrollment
- 225
- Locations
- 1
- Primary Endpoint
- Emotional Visual Event Related Potentials
- Status
- Completed
- Last Updated
- 2 months ago
Overview
Brief Summary
The purpose of this study is to study the efficacy and security of noninvasive brain stimulation as a new approach for patients with Substance Use Disorders (SUDs) plus other psychiatric conditions like ADHD, Schizophrenia, Bipolar disorder, etc.
Detailed Description
Background: There is an intimate relationship between addictive behaviors and other mental disorders, proven by clinical practice and many epidemiological studies, genetic and neuroscience. This gives risk to the diagnosis of Dual Pathology: an addiction and another mental disorder. Functional neuroimaging studies have shown that anterior cingulate cortex is associated with substance´s dependence and craving. Transcranial random noise stimulation (tRNS) stimulates parts of the brain and can change it´s activity. Researchers are interested in reduce cravings for substance dependence on patients with Dual Pathology using tRNS in anterior cingulate cortex. Aims: To determine whether tRNS in anterior cingulate cortex can reduce craving over Dual Pathology patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\> 18 years old and less than 60 years
- •Best-practice diagnosed Dual Pathology
- •Diagnosed since at least two years prior to enrollment.
- •Abuse more than 2 Substances
- •ExclusionC riteria:
- •Serious visual and hearing loss
- •Brain injury following cranial trauma
- •Other neurological disorders like Parkinson, ME, headache, etc.
- •Birth trauma
- •Mental retardation
Exclusion Criteria
- Not provided
Arms & Interventions
tRNS over Anterior Cingulate
Dual Pathology (Substance Use Disorder plus another psychiatric trait) 75 patients with diagnosed SUDs plus another psychiatric disorder will be receive tRNS in the disease-specific Anterior Cingulate Cortex (ACC), be studied blindly to evaluate the craving reduction after 35 tRNS sessions.
Intervention: Transcranial Random Noise Stimulation
tRNS applied over DLPFC
Dual Pathology (Substance Use Disorder plus another psychiatric trait) 75 patients with diagnosed SUDs plus another psychiatric disorder will be receive tRNS in the dorso-lateral-prefrontal-cortex (DLPFC), be studied blindly to evaluate the craving reduction after 35 tRNS sessions.
Intervention: Transcranial Random Noise Stimulation
Sham Group
75 patients will be receive tRNS sham 35 sessions.
Intervention: Transcranial Random Noise Stimulation
Outcomes
Primary Outcomes
Emotional Visual Event Related Potentials
Time Frame: Following patients during 3 months after Brain noninvasive estimulation
Emotional Visual Event Related Potentials responses (time courses and topographies) and ICA components related with them, identified by Mitsar 201M EEG Amplifier using EEGLab software \[ Time Frame: brainwaves patterns following an array of visual stimuli (human faces) during a 22 min. examination \]
AMEN Questionnarie
Time Frame: Following patients during 3 months after Brain noninvasive estimulation
100 Items Questionnarie subdivided in 5 subscales: basal ganglia, cingulate cortez, temporal cortex, prefrontal cortex and limbic system
Secondary Outcomes
- CAGE Adapted to Include Drugs (CAGE-AID)(Following 3 months after tRNS brain stimulation)