Transcranial Stimulation Combined With Auditory Training

Not Applicable

Not yet recruiting

• Conditions: Difficulties Understanding Speech in Noise

• Registration Number: NCT06738030
• Lead Sponsor: Boston University Charles River Campus

Brief Summary

The goal of this clinical trial is to learn if non-invasive brain stimulation (called transcranial stimulation) can enhance the benefits from auditory training in people who struggle to understand one talker when many people are talking at the same time. The main questions it aims to answer are:

* Does transcranial stimulation improve speech-on-speech understanding in people who struggle with this task?

* Does transcranial stimulation enhance the benefits of a commercially available auditory training program?

Researchers will compare transcranial stimulation to sham stimulation (no stimulation is applied during the listening task).

Participants will:

* Receive login information to an online auditory training program to complete at home over 2 weeks

* Visit the laboratory 4 times to receive transcranial stimulation while listening to speech-on-speech: once before at-home training, two times during the at-home training period, and once after at-home training has ended

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-12
• Study First Submitted: 2024-12-09
• Study First Submitted QC: 2024-12-12
• Last Update Submitted: 2024-12-12
• Study First Posted: 2024-12-17
• Last Update Posted: 2024-12-17
• Study Start: 2025-01-20
• Primary Completion: 2026-08
• Study Completion: 2026-08

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

• 50 years of age or older
• Audiometric thresholds that do not exceed 90 dB HL at any frequency from 250-6000 Hz
• Able to provide informed consent and understand experimental instructions
• Able to read print on a computer screen
• Difficulty with speech-on-speech understanding
• Access to computer or mobile phone with access to internet that can play sound (for the at-home training)

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Exclusion Criteria

• Non-native speakers of English
• History of skull fracture, scalp tissue damage, metallic implants around the head, seizures, neurological disorders, or traumatic brain injury, current or suspected pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Speech-on-speech intelligibility percent correct	From enrollment to the end of participation at 6 weeks	Percent correct score on the speech-on-speech task assessed in the lab
Pupillometry measured listening effort	From enrollment to the end of participation at 6 weeks	The peak pupil dilation subtracted from pre-trial baseline pupil dilation, averaged across trials in a block, assessed in the lab
QuickSIN SNR Loss	Days 1, 6, and 14 of the two-week auditory training	A speech-in-noise test assessed as part of the at-home auditory training program
Hearing Handicap Inventory	Days 1 and 14 of the two-week auditory training program	A listening effort questionnaire given as part of the at-home auditory training program

Trial Locations

Locations (1)

Communication Neuroscience Research Lab at Boston University; 🇺🇸 Boston, Massachusetts, United States