The direct effects of NSAIDS on osteoarthritic knee cartilage.
Completed
- Conditions
- Osteoarthritis of the knee is a progressing degenerative joint disorder, characterised by joint pain and limitation of movement, leading to disability. Tissue changes comprise damage of joint cartilage, synovial inflammation and changes in subchondral bone, such as subchondral sclerosis and osteophyte formation (bony outgrowths).
- Registration Number
- NL-OMON21305
- Lead Sponsor
- MC UtrechtRheumatology & Clin. Immunology
- Brief Summary
Arthritis Res Ther. 2006;8(1):R2.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 42
Inclusion Criteria
Patients with knee osteoarthritis according to the ACR criteria, considered for total knee replacement surgery.
Exclusion Criteria
1. Total knee replacement for other reason than osteoarthritis;
2. History of gastro-intestinal bleedings or perforation;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in proteoglycan release of osteoarthritic cartilage after treatment.
- Secondary Outcome Measures
Name Time Method ProsteoglandinE2 levels produced by cartilage.<br>