EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED CONTROLLED TRIAL (RCT).

Phase 4

Completed

• Conditions: Cyclooxygenase Two Inhibitors; Etoricoxib; Periodontitis; Superoxide Dismutase; Saliva
• Interventions: Drug: Etoricoxib

• Registration Number: NCT02149758
• Lead Sponsor: Tatyasaheb Kore Dental College

Brief Summary

The hypothesis is that Etoricoxib act as an adjuvant to SRP in alleviating periodontal inflammation by:

1. improving clinical periodontal parameters and,

2. improving the salivary SOD levels.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Status Verified: 2014-05
• Study First Submitted: 2014-05-26
• Study First Submitted QC: 2014-05-26
• Last Update Submitted: 2014-05-26
• Study First Posted: 2014-05-29
• Last Update Posted: 2014-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Forty patients with chronic generalized periodontitis

Exclusion Criteria

with system illnesses, allergies, pregnancy, history of any drug intake and periodontal treatment in past 6 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Etoricoxib	Etoricoxib	Etoricoxib 60 mg once daily
matching placebo	Etoricoxib	matching placebo once daily

Primary Outcome Measures

Name	Time	Method
change from baseline in salivary SOD level	3 months

Trial Locations

Locations (1)

Tatyasaheb kore Dental College And Research Centre; 🇮🇳 Kolhapur, Maharashtra, India