Oral Tolerance in Cow's Milk Allergy in the Infant
- Conditions
- Cow's Milk Allergy
- Registration Number
- NCT00298376
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
This study aims to determine if there is a link between cow's milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.
Cow's milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.
Number and function of regulatory T cells and microflora composition are measured at the same time.
Allergic infants are compared to age matched control group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk
Control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day
immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Alain Lachaux
🇫🇷Lyon, France