A Cross-sectional Study of Young-onset Diabetes in Two UK Ethnic Groups.
试验速览
- 阶段
- 不适用
- 入组人数
- 916
- 试验地点
- 1
- 主要终点
- Frequency of MODY
研究概览
简要总结
The purpose of this study is to describe and compare the different types of diabetes that exist in people from white European and south Asian origin in the UK (United Kingdom) who are diagnosed with diabetes before they turn 30 years old. By doing this we hope to identify cases of MODY (maturity onset diabetes of the young), which is a rare genetic cause of diabetes that is frequently misdiagnosed. Identifying MODY cases is important, as the treatment may differ to conventional treatment for type 1 or type 2 diabetes.
详细描述
People who meet the recruitment criteria, will be invited to attend for a single fasted 2 hour visit at our research facility. During the visit we will record details of their diabetes history as well as their general health and undertake blood and urine tests. At the end of the visit their participation will be complete. We will contact them later to discuss results of specialist blood tests and whether or not they have MODY, if they have had genetic testing performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with diabetes on the basis of fasting glucose and/or oral glucose tolerance test and/or HbA1c as per WHO criteria.
- •Diagnosed with diabetes between 6 months and 30 years of age.
- •South Asian ancestry- defined as self-reported ancestry and at least 2 grandparents from the Indian Subcontinent (India, Pakistan, Bangladesh or Sri Lanka).
- •European ancestry - defined as self-reported ancestry and at least 2 grandparents from within Europe.
排除标准
- •An established secondary cause of diabetes exists (for example recurrent pancreatitis, pancreatectomy, new onset diabetes after transplantation, Cushing's syndrome, acromegaly, steroid induced).
- •Enrolled in another study.
- •Have active malignancy or under investigation for malignancy.
结局指标
主要结局
Frequency of MODY
时间窗: 5 years
Comparison of frequency of MODY mutations between two ethnic groups
次要结局
- Comparison of biochemical and clinical characteristics in people with MODY between each ethnic group.(5 years)
- Comparison of clinical and biochemical characteristics of other subtypes of diabetes(5 years)