Detection of Microplastics in Cardiac Surgery Patients

Not yet recruiting

• Conditions: Microplastics; Nanoplastics; Cardiovascular Diseases; Cardiac Surgery
• Interventions: Other: Microplastics

• Registration Number: NCT05600010
• Lead Sponsor: Kun Hua

Brief Summary

The exponential growth in plastic production/use translates into a parallel increase in environmental plastic waste, which is constantly degraded into microplastics and nanoplastics. Information on the effects of microplastics on human health is still preliminary.

Cardiac surgery patients is a population high exposed to plastics. This observational study will obtain biological samples of cardiac surgery patients as a reference and vulnerable group of individuals highly exposed to microplastics and potentially more susceptible.

The objective of this research is to be able to detect microplastics on blood and operation samples of cardiac surgery patients as well as their potential genotoxic and immunological damage.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-10
• Study First Submitted: 2022-10-26
• Study First Submitted QC: 2022-10-26
• Study First Posted: 2022-10-31
• Last Update Submitted: 2022-10-31
• Study Start: 2022-11-01
• Last Update Posted: 2022-11-02
• Primary Completion: 2023-05-31
• Study Completion: 2023-10-22

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age ≥18 years
• Elective cardiac surgery

Exclusion Criteria

• Emergency surgery or limited-term surgery
• Previous cardiac surgery
• Previous severe liver disease
• Pregnant or planning to become pregnant
• Have a malignant tumor

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	Microplastics	Detection of microplastics/nanoplastics in heart tissue and the blood of patients undergoing cardiac surgery

Primary Outcome Measures

Name	Time	Method
Detection of microplastics in human heart tissue and the blood	perioperative: preoperative and pro-/postoperative blood and intraoperative heart tissue	Detection of microplastics in human heart tissue and the blood undergoing cardiac surgery