Impact of Anti-inflammatory and Antibiotic Therapy on the Emergence of Peri-tonsillar Abscess

Terminated

• Conditions: Abscess, Peritonsillar

• Registration Number: NCT00954031
• Lead Sponsor: Nantes University Hospital

Brief Summary

Analyze in children and adults, risk factors in the onset of the APA. The main hypothesis focuses on the use of anti-inflammatory in the context of pharyngitis or sore throat before the symptoms of ABS. Secondary objectives:

1. - Analyze the implementation of a rapid diagnostic test and its result on the occurrence of an ABS

2. - Measure the frequency of prescription and describe the reasons for not prescribing an antibiotic for patients who consulted for a sore throat and having developed a PLA

3. - Describe the microbial flora could puncture of patients hospitalized for APA

Detailed Description

Not available

Study Timeline

• Study Start: 2009-03
• Study First Submitted: 2009-08-05
• Study First Submitted QC: 2009-08-05
• Study First Posted: 2009-08-06
• Primary Completion: 2012-07
• Study Completion: 2012-07
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-30
• Last Update Posted: 2013-01-31

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 711

Inclusion Criteria

• clinical existence of a PLA (phlegmon), validated by a senior ENT, usually (but not necessarily) following a request by an emergency. The visible appearance to the merits throat must justify puncture. Cases will be included whether or not they had consulted for a "sore throat" in the 10 days preceding the date of diagnosis

Exclusion Criteria

• Neoplastic disease of the throat, scalable Hematologic with tonsillar localization History of tonsillectomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The principal judgement criterion of the study is the positive diagnosis of an APA. The explanatory variables to meet the main objective is the drug exposure (anti-inflammatory)	2,5 years

Secondary Outcome Measures

Name	Time	Method
The explanatory variables to meet the secondary objectives are: - The creation of a TDR - The prescription of antibiotics - The diagnosis of angina Strep Group A - The identification of a group A streptococcus in t	2,5 years

Trial Locations

Locations (15)

Paris-Lariboisière Hospital; 🇫🇷 Paris, France

Tours University Hosipital; 🇫🇷 Tours, France

Toulouse University Hospital; 🇫🇷 Toulouse, France

Lille University Hospital; 🇫🇷 Lille, France

Ambroise Paré Hospital; 🇫🇷 Paris, France

Paris-Bichat-Hospital; 🇫🇷 Paris, France

Paris-Tenon-Hospital; 🇫🇷 Paris, France

Poitiers University Hospital; 🇫🇷 Poitiers, France

Rennes University hospital; 🇫🇷 Rennes, France

Paris-Cochin Hospital; 🇫🇷 Paris, France

Caen universty Hospital; 🇫🇷 Caen, France

Clermont Ferrand University Hospital; 🇫🇷 Clermont Ferrand, France

Angers university Hospital; 🇫🇷 Angers, France

Grenoble University Hospital; 🇫🇷 Grenoble, France

Nantes University Hospital; 🇫🇷 Nantes, Pays de Loire, France