A Comparison of Three Nutritional Assessment Methods Predicting Prognosis in COPD With Respiratory Failure

Completed

• Conditions: Pulmonary Disease, Chronic Obstructive; Respiratory Insufficiency

• Registration Number: NCT02942784
• Lead Sponsor: West China Hospital

Brief Summary

This is a retrospective study of patients diagnosed with chronic obstructive pulmonary disease (COPD) with respiratory failure and admitted in West China Hospital during January 2014 to March 2016 by review of medical records. The following variables will be retrospectively studied: age, sex, marriage, height, weight, respiratory rate, PaO2, PaCO2, nutritional risk screening 2002 (NRS 2002) score, ALB, short-term and long-term prognostic outcomes, and so on. The purpose of this study is to compare the predictive power of three widely used nutritional assessment methods (BMI, NRS 2002 and ALB) predicting the prognostic outcomes in a cohort of COPD patients with respiratory failure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-10-10
• Study First Submitted QC: 2016-10-21
• Study First Posted: 2016-10-24
• Study Start: 2017-04-01
• Primary Completion: 2017-05-12
• Study Completion: 2017-05-12
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-18
• Last Update Posted: 2019-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 750

Inclusion Criteria

• Newly diagnosis of COPD at West China Hospital during January 2014 to March 2016
• Partial pressure of O2 (PaO2) < 60 mmHg and/or partial pressure of CO2 (PaCO2) >50 mmHg
• Age ≥ 18 years
• Respiratory rates > 23 bpm

Exclusion Criteria

• Pregnancy or during lactation
• Ventilatory dysfunction due to neuromuscular disorders, acute and chronic thromboembolic disease, severe illness in other systems
• Incomplete medical profiles

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Predictive value of nutritional assessment methods in identifying COPD patients with respiratory failure who will have poor prognosis, in terms of in-hospital death	up to 27 months
Predictive value of nutritional assessment methods in identifying COPD patients with respiratory failure who will have poor prognosis, in terms of 1-year death after discharge	up to 27 months
Predictive value of nutritional assessment methods in identifying COPD patients with respiratory failure who will have poor prognosis, in terms of 30-day readmission after discharge	up to 27 months

Secondary Outcome Measures

Name	Time	Method
Number of participants with 1-year death after discharge	up to 27 months
Number of participants with 30-day readmission after discharge	up to 27 months
Number of participants with in-hospital death	up to 27 months
Collection of Demographics (age, sex, marriage)	up to 27 months

Trial Locations

Locations (1)

West China Hospital; 🇨🇳 Chengdu, Sichuan, China