Can increased standing during the workday benefit metabolic health?

Not Applicable

Completed

• Conditions: Pre-diabetes; Impaired glucose tolerance; Impaired fasting glucose; Insulin resistance; Type 2 diabetes; Overweight/obesity; Metabolic and Endocrine - Diabetes; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12611000632998
• Lead Sponsor: Baker IDI Heart and Diabetes Institute

Brief Summary

Purpose: This study aimed to examine whether reductions in sitting time through alternating 30-min bouts of sitting and standing can reduce postprandial glucose, insulin, and triglyceride responses. Methods: Twenty-three overweight/obese sedentary office workers undertook two short-term (5 d) experimental conditions in an equal, randomized (1:1) order. In a simulated office environment, participants performed typical occupational tasks for 8 h/d while in a 1) seated work posture (control condition) or 2) interchanging between a seated and standing work posture every 30 min using an electric, height-adjustable workstation (intervention condition). Fasting and postprandial blood samples after a mixed test drink were collected hourly for 4 h on days 1 and 5 of each condition to assess serum insulin, plasma glucose, and triglycerides. Dietary intake and physical activity were standardized during each condition. Results: After adjustment for time (days 1 and 5), incremental area under the analyte time curve differed significantly between conditions for plasma glucose (P = 0.007) but not for serum insulin or plasma triglycerides. Mean glucose response curve was lowered by 11.1% after the intervention condition. Conclusions: Alternating standing and sitting in 30-min bouts results in modest beneficial effects on postprandial glucose

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-22
• Study Completion: 2013-05-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

males and females, overweight/obese (BMI 25-34.9 kg/m2), aged 35 to 65 years, employed full-time in typically sedentary (desk-bound) occupation, of English-speaking background

Exclusion Criteria

Key exclusion criteria: smoker, have a clinical history of cardiovascular disease, diabetes mellitus, thrombotic disease, musculoskeletal injury, regularly engage in high levels of exercise (> 300 minutes/wk of moderate-to-vigorous activity), taking prescription medications for hypertension and/or hyperlipidemia.

Study & Design

• Study Type: Interventional
• Study Design: Not specified