Prevention of Ovarian Hyperstimulation Syndrome in GnRH Agonist IVF Cycles: Randomized Study Comparing Hydroxyethyl Starch Versus Cabergoline and Hydroxyethyl Starch
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 主要终点
- risk of ovarian hyperstimulation syndrome
研究概览
简要总结
The purpose of this study is to assess whether, in GnRH agonist in vitro fertilization (IVF) cycles, where there is a risk of ovarian hyperstimulation syndrome (OHSS), the addition of cabergoline to the hydroxyethyl starch infusion could decrease OHSS incidence and severity.
详细描述
Women undergoing IVF cycles with GnRH agonist protocols, at risk of OHSS (more than 20 follicles observed larger than 12 mm in diameter and/or estradiol levels of 3000-5000 pg/mL).
Slow infusion of 500 ml of 6% HES during follicular aspiration alone or combined with 0.5 mg cabergoline administration for 8 days, starting on the day of hCG administration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •to be at risk of OHSS were invited to participate in the study
排除标准
- •age > 40 years
研究组 & 干预措施
Cabergoline
cabergoline
干预措施: Cabergoline and Hydroxyethyl Starch (Drug)
Cabergoline
cabergoline
干预措施: Hydroxyethyl Starch (Drug)
结局指标
主要结局
risk of ovarian hyperstimulation syndrome
时间窗: 12 days
次要结局
- pregnancy rate(15 days)
研究者
Roberto Matorras
Head of reproduction Unit
Hospital de Cruces