NCT00815594UnknownPhase 4
Bleb Vascularity Change After Subconjunctival Injection of Bevacizumab
Capital Medical University1 site in 1 country30 target enrollmentStarted: December 1, 2008Last updated:
Conditions
Drugs
Trial Snapshot
- Phase
- Phase 4
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- bleb vascular change
Study Overview
Brief Summary
The occurrence of conjunctival scarring finally leads to the obstruction of the fistula tract created by the filtering surgery. Vascular endothelial growth factor is thought to be a key role in the formation of conjunctival scar, which play a pivotal role in the wound-healing process. So it seems that the recombinant human anti-VEGF antibody could inhibit angiogenesis, and reduce the conjunctival vascular formation in the wound-healing process after glaucoma filtering surgery.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Glaucoma patients after trabeculectomy whose bleb is hyperaemia
Exclusion Criteria
- •Affected eye has normal IOP
- •Not allergic with Avastin
Outcomes
Primary Outcomes
bleb vascular change
Time Frame: one day, one week, one month
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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