The Influence of Preoperative Cardiopulmonary Capacity on the Perioperative Lactate Level

Completed

• Conditions: Sensitivity Training Groups; Complication, Cardio-respiratory

• Registration Number: NCT01819337
• Lead Sponsor: University of Witten/Herdecke

Brief Summary

The aim of this study is to identify if there exists a correlation between the preoperative cardiopulmonary capacity - measured in MET's - and the perioperative lactate serum level.

Detailed Description

The determination of the cardiopulmonary (c/p) capacity is very important for the evaluation of every patient undergoing surgery. The ability to climb at least two flight of stairs is seen to be an acceptable c/p capacity for surgery. There are several ways to evaluate the fitness of patients. A common method to estimate the cardiopulmonary capacity is defining patients through the MET's (metabolic equivalents) scale. MET's can be defined relatively easy through a simple questionnaire. Patients with a reduced c/p capacity have less than 4 MET's, patients with a relatively good c/p capacity have 4-10 MET's and patients with a excellent c/p capacity have more than 10 MET's.

The lactate level in blood serum is a common parameter to asses anaerobic metabolism in patients. A high lactate level correlates with higher mortality rates and outcome.

To yet it is not clear if there exists a correlation between the preoperative cardiopulmonary capacity measured in MET's and the perioperative lactate level. We hypothysed that patients with a reduced cardiopulmonary capacity are associated with higher perioperative lactate levels, as these group of patients compensate the stressors operation/anesthesia less than patients with a good c/p capacity.

Study Timeline

• Study First Submitted: 2013-02-08
• Study Start: 2013-03
• Study First Submitted QC: 2013-03-26
• Study First Posted: 2013-03-27
• Primary Completion: 2013-04
• Study Completion: 2013-08
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-15
• Last Update Posted: 2013-09-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1502

Inclusion Criteria

• Age > 18 years

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Exclusion Criteria

• Cardiac surgery

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
lactate - venous blood gas analysis	venous lactate will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours	mmol/l

Secondary Outcome Measures

Name	Time	Method
icu in hospital mortality	icu patients will be followed over their hospital stay over a maximum period of 6 months
hemoglobin - venous blood gas analysis	hemoglobin will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours	g/dl
icu ventilation time	icu patients will be followed over their hospital stay over a maximum period of 6 months	hours/days

Trial Locations

Locations (1)

Helios Klinikum Wuppertal; 🇩🇪 Wuppertal, NRW, Germany