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临床试验/NCT01819337
NCT01819337已完成不适用

The Influence of Preoperative Cardiopulmonary Capacity Mesured in MET's (Metabolic Equivalents) on the Perioperative Lactate Level

University of Witten/Herdecke1 个研究点 分布在 1 个国家目标入组 1,502 人开始时间: 2013年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
1,502
试验地点
1
主要终点
lactate - venous blood gas analysis

研究概览

简要总结

The aim of this study is to identify if there exists a correlation between the preoperative cardiopulmonary capacity - measured in MET's - and the perioperative lactate serum level.

详细描述

The determination of the cardiopulmonary (c/p) capacity is very important for the evaluation of every patient undergoing surgery. The ability to climb at least two flight of stairs is seen to be an acceptable c/p capacity for surgery. There are several ways to evaluate the fitness of patients. A common method to estimate the cardiopulmonary capacity is defining patients through the MET's (metabolic equivalents) scale. MET's can be defined relatively easy through a simple questionnaire. Patients with a reduced c/p capacity have less than 4 MET's, patients with a relatively good c/p capacity have 4-10 MET's and patients with a excellent c/p capacity have more than 10 MET's.

The lactate level in blood serum is a common parameter to asses anaerobic metabolism in patients. A high lactate level correlates with higher mortality rates and outcome.

To yet it is not clear if there exists a correlation between the preoperative cardiopulmonary capacity measured in MET's and the perioperative lactate level. We hypothysed that patients with a reduced cardiopulmonary capacity are associated with higher perioperative lactate levels, as these group of patients compensate the stressors operation/anesthesia less than patients with a good c/p capacity.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age > 18 years

排除标准

  • Cardiac surgery

结局指标

主要结局

lactate - venous blood gas analysis

时间窗: venous lactate will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours

mmol/l

次要结局

  • hemoglobin - venous blood gas analysis(hemoglobin will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours)
  • icu in hospital mortality(icu patients will be followed over their hospital stay over a maximum period of 6 months)
  • icu ventilation time(icu patients will be followed over their hospital stay over a maximum period of 6 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Armin Zagler

MD

University of Witten/Herdecke

研究点 (1)

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