The Influence of Preoperative Cardiopulmonary Capacity Mesured in MET's (Metabolic Equivalents) on the Perioperative Lactate Level
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,502
- 试验地点
- 1
- 主要终点
- lactate - venous blood gas analysis
研究概览
简要总结
The aim of this study is to identify if there exists a correlation between the preoperative cardiopulmonary capacity - measured in MET's - and the perioperative lactate serum level.
详细描述
The determination of the cardiopulmonary (c/p) capacity is very important for the evaluation of every patient undergoing surgery. The ability to climb at least two flight of stairs is seen to be an acceptable c/p capacity for surgery. There are several ways to evaluate the fitness of patients. A common method to estimate the cardiopulmonary capacity is defining patients through the MET's (metabolic equivalents) scale. MET's can be defined relatively easy through a simple questionnaire. Patients with a reduced c/p capacity have less than 4 MET's, patients with a relatively good c/p capacity have 4-10 MET's and patients with a excellent c/p capacity have more than 10 MET's.
The lactate level in blood serum is a common parameter to asses anaerobic metabolism in patients. A high lactate level correlates with higher mortality rates and outcome.
To yet it is not clear if there exists a correlation between the preoperative cardiopulmonary capacity measured in MET's and the perioperative lactate level. We hypothysed that patients with a reduced cardiopulmonary capacity are associated with higher perioperative lactate levels, as these group of patients compensate the stressors operation/anesthesia less than patients with a good c/p capacity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > 18 years
排除标准
- •Cardiac surgery
结局指标
主要结局
lactate - venous blood gas analysis
时间窗: venous lactate will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours
mmol/l
次要结局
- hemoglobin - venous blood gas analysis(hemoglobin will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours)
- icu in hospital mortality(icu patients will be followed over their hospital stay over a maximum period of 6 months)
- icu ventilation time(icu patients will be followed over their hospital stay over a maximum period of 6 months)
研究者
Armin Zagler
MD
University of Witten/Herdecke
