NCT00139945CompletedNot Applicable
Effects of Acute Ghrelin Infusion to Growth Hormone Deficient Adults: Growth Hormone and Cortisol Interaction
Conditions
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Aarhus
- Enrollment
- 8
- Locations
- 2
- Primary Endpoint
- Endogenous serum ghrelin levels
Study Overview
Brief Summary
In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age between 18 and 60 yrs.
- •Verified hypopituitarism
- •Unchanged substitution treatment through 3+ months
- •Unchanged additional medical treatment
- •Oral and written informed consent
Exclusion Criteria
- •Age below 18 or above 60 yrs.
- •Diabetes mellitus
- •body mass index > 30
- •Fasting hypoglycemia
- •Convulsions
- •Allergy to trial products
Outcomes
Primary Outcomes
Endogenous serum ghrelin levels
Time Frame: Same day as intervention
Secondary Outcomes
- Insulin sensitivity, appetite, metabolism, intracellular signal transduction(Same day as intervention)
Investigators
Study Sites (2)
Loading locations...
Similar Trials
Completed
Not Applicable
Diagnosing Adult Growth Hormone DeficiencyGrowth Hormone DeficiencyNCT03018886Helsinki University Central Hospital160
Completed
Not Applicable
Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Premature PubertyPuberty, PrecociousNCT02431416Region Örebro County13
Completed
Phase 2
Influence of exogenous growth hormone administration on circulating levels of Klotho in healthy and chronic kidney disease subjectsrenal insufficiencyChronic kidney diseaseNL-OMON40366Vrije Universiteit Medisch Centrum20
Active, not recruiting
Not Applicable
Influence of growth hormone administered subcutaneously on circulating Klotho levels in healthy subjects and subjects with renal failure.Cardiovascular disease in chronic kidney diseaseEUCTR2013-003354-24-NLVrij Universiteit Medical Center
Completed
Not Applicable
Influence of exogenous growth hormone administration on circulating levels of Klotho in paediatric patients with isolated growth hormone deficiency.Klotho levels in isolated growth hormone deficiency10021112NL-OMON44245Vrije Universiteit Medisch Centrum20
