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Clinical Trials/NCT00139945
NCT00139945CompletedNot Applicable

Effects of Acute Ghrelin Infusion to Growth Hormone Deficient Adults: Growth Hormone and Cortisol Interaction

University of Aarhus2 sites in 1 country8 target enrollmentStarted: October 2005Last updated:
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Conditions
Drugs

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
8
Locations
2
Primary Endpoint
Endogenous serum ghrelin levels
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Age between 18 and 60 yrs.
  • •Verified hypopituitarism
  • •Unchanged substitution treatment through 3+ months
  • •Unchanged additional medical treatment
  • •Oral and written informed consent

Exclusion Criteria

  • •Age below 18 or above 60 yrs.
  • •Diabetes mellitus
  • •body mass index > 30
  • •Fasting hypoglycemia
  • •Convulsions
  • •Allergy to trial products

Outcomes

Primary Outcomes

Endogenous serum ghrelin levels

Time Frame: Same day as intervention

Secondary Outcomes

  • Insulin sensitivity, appetite, metabolism, intracellular signal transduction(Same day as intervention)

Investigators

Sponsor Class
Other

Study Sites (2)

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