Influence of exogenous growth hormone administration on circulating levels of Klotho in paediatric patients with isolated growth hormone deficiency.

Completed

• Conditions: Klotho levels in isolated growth hormone deficiency; 10021112

• Registration Number: NL-OMON44245
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Subjects with newly diagnosed GHD according to the guideline *Guideline for GH treatment in children* with an indication for treatment with rhGH .
- Boys < 9 years old and girls < 8 years old (pre-pubertal).
- No history of rhGH treatment in the last 6 months.
- Providing informed consent by the parents.

Exclusion Criteria

- Subjects with a combined pituitary hormone deficiency.
- Patients taking medications or having concomitant illnesses likely to confound endpoint assessments (e.g.use of corticosteroids, androgens or anabole steroids, insulin).
- Patients with hypothyroidism not adequately supplied with thyroid hormone.
- Patients taking other experimental (i.e., non marketed) therapies.
- Patients with any kind of kidney disease.
- Patients with a single kidney.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The absolute change in sKlotho levels in serum and urine before and after<br /><br>treatment with rhGH in paediatric patients with IGHD.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable.</p><br>