Candidemia in a Pediatric Center and Importance of Central Venous Catheter Removal

Completed

• Conditions: Candidemia

• Registration Number: NCT02088476
• Lead Sponsor: Hacettepe University

Brief Summary

Candidemia has emerged as an important cause of hospital-associated blood-stream infection in children. The purpose of this study was to identify differences in distribution of candida species, risk factors, treatment, and clinical outcome of candidemia in children. This study in children ≤18 years with blood culture proven candidemia identified between 2004 and 2012. Analyses included the determination of causative candida species, resistance to antifungals and clinical outcome, as well as the identification of potential risk factors associated with candidemia.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-01
• Primary Completion: 2012-12
• Study Completion: 2013-06
• Status Verified: 2014-03
• Study First Submitted: 2014-03-10
• Study First Submitted QC: 2014-03-14
• Last Update Submitted: 2014-03-14
• Study First Posted: 2014-03-17
• Last Update Posted: 2014-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 248

Inclusion Criteria

• Presence of growth of any candida species in at least one blood culture

Exclusion Criteria

• Febrile neutropenic patients who were using empirical antifungal agents

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Risk factors of candidemia	up to 3 months	The presence or absence of potential risk factors for candidemia such as an indwelling central venous catheter (CVC), use of antibiotics (administered for \>72 hours), use of antifungals (administered for \>24 hours), immunosuppressants, total parenteral nutrition (TPN), admission to the intensive care unit (ICU), mechanical ventilation, neutropenia, hypoalbuminemia and hypophosphatemia.

Secondary Outcome Measures

Name	Time	Method
Prognosis according to candida species	up to 3 months	Death which ensues within 30 days of the onset of candidemia with no apparent alternative cause is recognized as a candidemia-attributable mortality. Patients who died and survived were compared according to candida species (C.albicans, C. parapsilosis, C. tropicalis, C. sake, C.glabrata).

Trial Locations

Locations (1)

Hacettepe University Faculty of Medicine; 🇹🇷 Ankara, Turkey