Multimodal prospective analysis of biomarkers for Critical-Illness-Polyneuromyopathy.

• Conditions: G62.80; G72.80

• Registration Number: DRKS00012491
• Lead Sponsor: Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-11
• Study Completion: 2022-04-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Voluntariness; written confirmed consent; adequate knowledge of German language; 18 years of age, = 7 days stay on ICU incl. at least 3 days ventilation during the last ten years

Exclusion Criteria

< 18 years; withdrawal of agreement; employees of the researching medic, or the facility which is participating in this clinical research or other studies; simultaneous participation in an AMG-study; CCM: opthalmic surgery within the last 3 months, MRI: metal implantans, QST: skin disorder in area of investigation.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of CIPNM (Critical-Illness-Polyneuromyopathy); frequency of abnormal parameters in ENoG (electroneurography, EMG (electromyography), CCM (corneal confocal microscopy), QST (quantitative sensory testing), MRI (magnetic resonance imaging), skin biopsy; determination of sensitivity and specificity of individual parameters

Secondary Outcome Measures

Name	Time	Method
Correlation of values of all investigations among each other