Vegetable intake and blood pressure study

Not Applicable

Completed

• Conditions: Cardiovascular disease; Hypertension; Cardiovascular - Hypertension; Diet and Nutrition - Other diet and nutrition disorders; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12615000194561
• Lead Sponsor: The University of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Ambulant men and women;
21-75 years; and
Systolic blood pressure 120-160 mm Hg.

Exclusion Criteria

Systolic blood pressure less than 120 mm Hg or greater than 160 mm Hg;
Diastolic blood pressure greater than 100 mm Hg;
Diagnosed type 1 or 2 diabetes or fasting glucose greater than 7.0mmol/L;
Consumption of a diet estimated to contain greater than 200 mg/day of nitrate (volunteers willing to limit nitrate-rich vegetables for a period of 4 weeks before their lead in visit may be included);
Consumption of greater than or equal to 5 serves of vegetables per day;
Being vegan or vegetarian;
Body mass index less than 18.5 kg/m2 and body mass index greater than or equal to 35 kg/m2;
Use of antihypertensive medication;
Use of nitric oxide donors, organic nitrites and nitrates, sildenafil and/or related drugs;
Use of antibacterial mouth wash (volunteers willing to cease using antibacterial mouth wash for a period of 4 weeks before their lead in visit may be included);
Use of antibiotics (within previous 2 months);
Current or recent (less than 12 months) smoking;
History of symptomatic cardiovascular or peripheral vascular disease or chronic kidney disease;
Recent history of a psychiatric illness or other major illnesses such as cancer;
A change in drug therapy likely to influence blood pressure or major secondary outcomes within the previous 3 months, and/or the likelihood that drug therapy would change during the study;
Current or recent (within previous 6 months) significant weight loss or gain (greater than 6% of body weight);
Alcohol intake greater than 140 g per week for women or greater than 210 g per week for men and/or binge drinking behaviour;
Reported participation in night shift work during the study period;
Breastfeeding, pregnancy or planning of pregnancy; and
Inability or unwillingness to follow the study protocol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified