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Clinical Trials/NCT00353795
NCT00353795
Completed
N/A

Coronary Atherosclerosis Evaluation by Arterial Wall MRI

Johns Hopkins University2 sites in 1 country179 target enrollmentJuly 2005

Overview

Phase
N/A
Intervention
Not specified
Conditions
Coronary Arteriosclerosis
Sponsor
Johns Hopkins University
Enrollment
179
Locations
2
Primary Endpoint
Mean Coronary Wall Thickness
Status
Completed
Last Updated
15 years ago

Overview

Brief Summary

The overall goal of this study is to use MRI to:

  • Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
  • Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
  • Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

Detailed Description

Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes

Registry
clinicaltrials.gov
Start Date
July 2005
End Date
June 2008
Last Updated
15 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
  • Male or Female adult equal to or older than 45 years of age
  • Willing/able to provide informed consent

Exclusion Criteria

  • Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
  • Metal in the eyes

Outcomes

Primary Outcomes

Mean Coronary Wall Thickness

Time Frame: n/a (cross sectional analysis)

Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).

Study Sites (2)

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