NCT00353795
Completed
N/A
Coronary Atherosclerosis Evaluation by Arterial Wall MRI
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Coronary Arteriosclerosis
- Sponsor
- Johns Hopkins University
- Enrollment
- 179
- Locations
- 2
- Primary Endpoint
- Mean Coronary Wall Thickness
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
The overall goal of this study is to use MRI to:
- Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
- Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
- Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.
Detailed Description
Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes
Investigators
Eligibility Criteria
Inclusion Criteria
- •Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
- •Male or Female adult equal to or older than 45 years of age
- •Willing/able to provide informed consent
Exclusion Criteria
- •Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
- •Metal in the eyes
Outcomes
Primary Outcomes
Mean Coronary Wall Thickness
Time Frame: n/a (cross sectional analysis)
Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).
Study Sites (2)
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