The Efficacy of Intravenous Paracetamol Versus Dexketoprofen for Postoperative Pain Management After Septoplasty: A Prospective Randomized Double Blind Study
Overview
- Phase
- Phase 3
- Intervention
- Paracetamol
- Conditions
- Postoperative Pain
- Sponsor
- Baskent University
- Enrollment
- 2
- Primary Endpoint
- Change from pain scores until postoperative 24 hours
- Last Updated
- 10 years ago
Overview
Brief Summary
The investigators conducted a prospective, randomized, double blind study to compare the effectiveness of intravenous paracetamol and dexketoprofen for preventing pain during first 24 hours postoperative period in adult patient undergoing septoplasty.
Detailed Description
Postoperative pain scores as measured by Visual Analog Scale (VAS) (0 represented no pain and 10 the worst pain ever experienced) at 15, 30, 60 minutes and 2th, 4th, 6th, 12th and 24th hours postoperatively.
Investigators
Esra Caliskan
Associated Professor
Baskent University
Eligibility Criteria
Inclusion Criteria
- •After patient's inform consent was approved, a total of 70 ASA (American Society of Anesthesiology) physical status I and II adult patients age 18 to 65 undergoing septoplasty were planned include the study.
Exclusion Criteria
- •History of clotting disorders or blood dyscrasias,
- •Gastrointestinal ulcer or chronic dyspepsia,
- •History of allergy to the study drugs,
- •Active bleeding or bleeding disorders.
Arms & Interventions
Paracetamol
1 gr paracetamol received intravenously bolus 15 minutes after anesthetic induction and at the postoperative 6 th,12 th, 18 th and 24 th hours
Intervention: Paracetamol
Dexketoprofen
50 mg dexketoprofen received intravenous bolus 15 minutes after anesthetic induction and at the postoperative 8 th,16 th and 24 th hours.
Intervention: Dexketoprofen
Outcomes
Primary Outcomes
Change from pain scores until postoperative 24 hours
Time Frame: Pain scores recorded during postoperative 24 hours.
Pain scores as measured by Visual Analog Scale (VAS) at 15 and 30 minutes, 1h, 2h, 4h, 6h, 12h, and 24 h after surgery
Secondary Outcomes
- Cumulative tramadol consumption during postoperative 24 hours.(First postoperative 24 hours)