Determine the Effect of Prone Positioning in Adults With ARDS by Electrical Impedance Tomography

• Conditions: ARDS; Prone Position; Electrical Impedance Tomography

• Registration Number: NCT04725227
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

determine the effect of prone positioning on ventilation and perfusion distribution in adults with acute respiratory distress syndrome by electrical impedance tomography

Detailed Description

By intravenous injection of a small amount of normal saline, electrical impedance tomography enables evaluation of the pulmonary blood flow. EIT might be helpful in establishing the hypoxemia etiology at bedside via combining regional ventilation and perfusion information. The objective of this study was to describe the physiological effects of prone position on respiratory mechanics, ventilation and pulmonary perfusion in patients with ARDS.

Study Timeline

• Study Start: 2020-12-01
• Status Verified: 2021-01
• Study First Submitted: 2021-01-25
• Study First Submitted QC: 2021-01-25
• Last Update Submitted: 2021-01-25
• Study First Posted: 2021-01-26
• Last Update Posted: 2021-01-26
• Primary Completion: 2022-12-01
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• patients who were undergoing mechanical ventilation with moderate-to-severe ARDS (defined as a Pao2:Fio2 ratio < 150 mm Hg with a positive end-expiratory pressure ≥ 5 cm of water, and an Fio2 of ≥ 0.6) according to the Berlin definition

Exclusion Criteria

• contraindications to the use of EIT (e.g., presence of pacemaker or chest surgical wounds dressing)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess regional distribution of pulmonary perfusion	within 24 hours	To evaluate the effect of prone positon on pulmonary blood flow distribution.
Assess oxygenation status	within 24 hours	To evaluate the effect of prone position by assessing regional distribution of pulmonary perfusion based on indicator dilution and changes at different points in time during varying states of regional ventilation will be evaluated.
Assess regional distribution of pulmonary ventilation	within 24 hours	To evaluate the effect of prone positon on pulmonary vetilation distribution.

Trial Locations

Locations (1)

Zhongshan Hospital of Fudan University; 🇨🇳 Shanghai, Shanghai, China