The effect of acute whole-body heat exposure on liver insulin sensitivity and substrate metabolism - Heat and hepatic insulin sensitivity

niversiteit Maastricht0 个研究点目标入组 14 人开始时间: 待定最近更新: 2024年4月15日

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all
•of the following criteria:
•* Signed informed consent
•* Men and women
•* Caucasian / white western European
•* Aged 45-65 years at the start of the study
•* Body mass index (BMI) 27-35 kg/m2
•* Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3
•* Stable sedentary lifestyle (not more than 2 hours of sports per week)
•* Women after their menopause, meaning cessation of menses for at least 24
•months) and only if they are not under hormonal treatment
•* Suitable veins for cannulation or repeated venapuncture
•* Generally healthy, no medication use that interferes with metabolism, no
•signs of active cardiovascular disease, liver or kidney malfunction. If
•volunteers need medication, it will be reviewed with the dependent physician on
•individual basis.

•A potential subject who meets any of the following criteria will be excluded
•from participation in this study:
•* Type 2 Diabetes
•* Men Haemoglobin <8.4mmol/L, women haemoglobin <7.8 mmol/L
•* Signs of active uncontrolled hypertension, liver or kidney malfunction
•* Cardiac problems and cardiovascular diseases, such as congestive heart
•failure, angina pectoris, cardiac infarction and arrhythmias
•* Any medical condition requiring treatment and/or medication that might
•interfere with the investigated parameters. All medical conditions/medications
•will be reviewed with the dependent physician and in-/exclusion will be decided
•on individual basis
•* Unstable body weight (weight gain or loss >3kg in the past three months)
•* Participation in another biomedical study within 1 month prior to screening
•* Participants, who do not want to be informed about unexpected medical
•findings, or do not wish that their treating physician will be informed, cannot
•participate in this study
•* Blood donation three month prior to study and three month after finishing
•* Alcohol consumption of >2 servings per day for men and >1 serving per day for
•* Smoking in the past 6 months
•A medical doctor will judge participation eligibility based on the medical
•history questionnaire, medication use and fasting blood parameters. If the
•medical doctor advises that someone cannot participate, they will be excluded
•from enrolment.

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