The effect of acute whole-body heat exposure on hepatic insulin sensitivity and substrate metabolism

Maastricht University0 个研究点目标入组 14 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•Signed informed consent
•Men and women
•Caucasian / white western European
•Aged 40-70 years at the start of the study
•Body mass index (BMI) 25-35 kg/m2
•Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3
•Stable sedentary lifestyle (not more than 2 hours of sports per week)
•Women after their menopause, meaning no menstrual cycle for at least 24 months and only if they are not under hormonal treatment.
•Generally healthy, no medication use that interferes with metabolism. If volunteers need medication, it will be reviewed with the dependent physician on individual basis.

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•Haemoglobin <8.4mmol/L
•Use of cholesterol or lipid-lowering medication
•Active pregnancy
•No signs of active uncontrolled hypertension, liver or kidney malfunction
•Cardiac problems and cardiovascular diseases, such as angina pectoris, cardiac infarction and arrhythmias
•Any medical condition requiring treatment and/or medication that might interfere with the investigated parameters. All medical conditions/medications will be reviewed with the dependent physician and in-/exclusion will be decided on individual basis
•Anticoagulation medication
•Unstable body weight (weight gain or loss >3kg in the past three months)
•Participation in another biomedical study within 1 month prior to screening visit
•Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study
•Blood donation three months prior to study and three months after finishing the study
•Alcohol consumption of >2 servings per day Smoking in the past 6 months
•Women if they don’t take oral contraceptives for at least 3 menstrual cycle

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