NCT06596070尚未招募不适用
Clinical Study of Intestinal Barrier Dysfunction in Patients After Gastrointestinal Surgery
The Second Affiliated Hospital of Kunming Medical University0 个研究点目标入组 180 人开始时间: 2024年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 180
- 主要终点
- operating time
研究概览
简要总结
The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •men or women aged 18-80 years
- •expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection)
- •no preoperative intestinal barrier dysfunction
- •patients voluntarily participated in this study and signed an informed consent form.
排除标准
- •Patients or their families refused to participate in this study
- •chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.)
- •history of antibiotic administration in the last 2 weeks
- •severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy
- •combined with severe hepatic, renal, and cardiac insufficiency patients.
结局指标
主要结局
operating time
时间窗: During surgery
Record the patient\'s surgical time
次要结局
- nutritional status(Preoperative)
- bowel habit(Preoperative)
- Surgical Procedures(During surgery)
- hemorrhage(During surgery)
- Albumin(Preoperative and postoperative 24 hours)
- Infection indicators(Preoperative and postoperative 24 hours)
- age(Preoperative)
- gender(Preoperative)
- Body Mass Index(Preoperative)
- diabetes(Preoperative)
- enteral nutrition(The average observation time is 2 weeks after surgery.)
- Exhaust and defecation time(The average observation time is one week after surgery)
研究者
Weiming Li
Investigator
The Second Affiliated Hospital of Kunming Medical University
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