NCT00612950已完成不适用
Four Weeks of Near Normalisation of Blood Glucose Improves the Insulin Response to GLP-1 and GIP in Patients With Type 2 Diabetes
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- 2.phase insulin response measured as incremental area under the curve from 10-120 minutes
研究概览
简要总结
The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-70 years
- •Type 2 diabetes diagnosed after 30 years of age
- •BMI > 25
排除标准
- •Severe complications to diabetes
- •Abnormal liver and kidney function
- •Haemoglobin below the lower limit
- •Macroalbuminuria
- •Systemic disease
- •Pregnancy
研究组 & 干预措施
GLP-1
Experimental
干预措施: glucagon-like peptide-1, (Drug)
GIP
Experimental
干预措施: glucose dependent insulinotropic polypeptide (Drug)
saline
Placebo Comparator
干预措施: Saline (Drug)
结局指标
主要结局
2.phase insulin response measured as incremental area under the curve from 10-120 minutes
时间窗: 2 hours
次要结局
- 2.phase insulin response measured as incremental area under the curve from 10-120 minutes, after 4 weeks of insulin treatment(2 hours)
研究者
研究点 (1)
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