Exploring the Effects of an 8-week Turmeric Supplementation on Aspects of Physiology and Wellbeing in Healthy Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Plasma/serum Brain-derived neurotrophic factor
研究概览
简要总结
Curcumin (a bioactive compound found in turmeric) has demonstrated anti-inflammatory and antioxidant properties, and there is evidence to suggest that it may produce improvements in quality of life and markers of health in humans with various conditions. To date, the research has often focussed on the effects of curcumin in human participants with a particular condition. However, turmeric contains hundreds of other bioactive compounds (including other curcuminoids and essential oils) and may be able to benefit a wide range of older adults. Therefore, the aim of this study is to investigate the effects of twice daily consumption of a turmeric beverage for 8-weeks on the physiology and wellbeing of older adults (versus placebo).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Body Mass Index between 18.5-35.
排除标准
- •History of, or currently diagnosed with, a cardiovascular disease.
- •Diagnosed with diabetes.
- •Diagnosed with a liver, lung, or kidney disease.
- •Diagnosed with osteoporosis.
- •Diagnosed with dementia.
- •Diagnosed with cancer.
- •Use of medications/supplements/herbal remedies with human evidence of a significant interaction with turmeric.
- •Allergy to turmeric, lemon, black pepper, watermelon, water, pineapple, magnesium or vitamin C.
- •Pregnant, attempting to become pregnant, or breastfeeding.
- •Regular (once per week or more) use of turmeric shots / supplements within the last 3 months.
结局指标
主要结局
Plasma/serum Brain-derived neurotrophic factor
时间窗: Two timepoints: 1) baseline 2) after 8 week intervention
Measured using ELISA. We will analyse raw and percentage change values.
Plasma/serum total cholesterol
时间窗: Two timepoints: 1) baseline 2) after 8 week intervention
Measured using pentra C400 clinical chemistry analyser, We will analyse raw and percentage change values.
Chalder Fatigue Scale (CFS)
时间窗: Two timepoints: 1) baseline 2) after 8 week intervention
This questionnaire measures participants' severity of physical and mental fatigue. This will be scored "Likert style" from 0-33. Higher scores indicate greater levels of fatigue.
次要结局
- Physical activity levels(Two one week periods: first week of intervention (week 1) and last week of intervention (week 8))
- McGill Pain Questionnaire(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum AST(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum LDL cholesterol(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum HDL cholesterol(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum ALP(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum ALT(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum creatinine(Two timepoints: 1) baseline 2) after 8 week intervention)
- Depression Anxiety Stress Scales - 21 items (DASS-21)(Two timepoints: 1) baseline 2) after 8 week intervention)
- 36-Item Short Form Survey (SF-36)(Two timepoints: 1) baseline 2) after 8 week intervention)
- Serum GGT(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum LDH(Two timepoints: 1) baseline 2) after 8 week intervention)
- Pittsburgh Sleep Quality Index (PSQI)(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum creatine kinase(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum triglycerides(Two timepoints: 1) baseline 2) after 8 week intervention)
- N-back task for working memory (cognitive function)(Two timepoints: 1) baseline 2) after 8 week intervention)
- Corsi forward block test for visuospatial working memory (cognitive function)(Two timepoints: 1) baseline 2) after 8 week intervention)
- Corsi backward block test for visuospatial working memory (cognitive function)(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum C-reactive protein(Two timepoints: 1) baseline 2) after 8 week intervention)
- Plasma/serum glucose(Two timepoints: 1) baseline 2) after 8 week intervention)
- Blood pressure(Two timepoints: 1) baseline 2) after 8 week intervention)
- Body mass(Two timepoints: 1) baseline 2) after 8 week intervention)
- Sit-to-Stand Test(Two timepoints: 1) baseline 2) after 8 week intervention)
- Hand Grip Strength Test(Two timepoints: 1) baseline 2) after 8 week intervention)
- 2-minute Step Test(Two timepoints: 1) baseline 2) after 8 week intervention)
- Waist circumference(Two timepoints: 1) baseline 2) after 8 week intervention)
- Waist to hip ratio(Two timepoints: 1) baseline 2) after 8 week intervention)
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)(Two timepoints: 1) baseline 2) after 8 week intervention)
- Physical activity levels(Two one week periods: One week prior to intervention (baseline) and last week of intervention (week 8))
- Pain medication usage(Two timepoints: 1) Baseline 2) after 8 week intervention)
研究者
John Hough
Associate Professor in Health and Immunology
Nottingham Trent University