Correlation Between Sex and Prognosis of Acute Aortic Dissection in the Chinese Population

Completed

• Conditions: Sex Role; Acute Aortic Dissection
• Interventions: Drug: drug; Procedure: Surgery

• Registration Number: NCT03381716
• Lead Sponsor: Shenyang Northern Hospital

Brief Summary

The study evaluated the prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex.

Detailed Description

The study included 884 patients enrolled in our institute between June 2002 and May 2016. Considering psychosocial factors, treatments, and the outcomes in men versus those in women with acute aortic dissection, explored the association of sex with psychosocial characteristics and mortality risk. Of 884 patients, 211 (23.9%) were women. The median duration of follow-up was 2.9 years (25th -75th percentiles: 1-4 years ).

Study Timeline

• Study Start: 2002-06-19
• Primary Completion: 2016-05-29
• Study Completion: 2016-05-29
• Status Verified: 2017-12
• Study First Submitted: 2017-12-11
• Study First Submitted QC: 2017-12-18
• Last Update Submitted: 2017-12-18
• Study First Posted: 2017-12-22
• Last Update Posted: 2017-12-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 884

Inclusion Criteria

• acute aortic dissection

Exclusion Criteria

• Chronic aortic dissection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
female	Surgery	Drug:Beta-blocker,Angiotensin II receptor blocker,Angiotensin-converting enzyme,Calcium-channel blocker,Aspirin,Statin
male	Surgery	Drug:Beta-blocker,Angiotensin II receptor blocker,Angiotensin-converting enzyme,Calcium-channel blocker,Aspirin,Statin
female	drug	Drug:Beta-blocker,Angiotensin II receptor blocker,Angiotensin-converting enzyme,Calcium-channel blocker,Aspirin,Statin
male	drug	Drug:Beta-blocker,Angiotensin II receptor blocker,Angiotensin-converting enzyme,Calcium-channel blocker,Aspirin,Statin

Primary Outcome Measures

Name	Time	Method
The outcome measure describes aortic disease-related death，aortic dissection, paraplegia, myocardial ischemia, renal insufficiency and other aortic complications.	2.9years	The study's primary endpoint during the follow up was the composite of aortic disease-related death, aortic dissection, paraplegia, myocardial ischemia, renal insufficiency and other aortic complications during follow-up.