Use of Dexamethasone in Uterine Artery Embolization
Not Applicable
Completed
- Conditions
- AdenomyosisUterine Myoma
- Interventions
- Drug: Normal saline
- Registration Number
- NCT02056717
- Lead Sponsor
- Severance Hospital
- Brief Summary
The primary purpose of this study is to investigate the effects of dexamethasone on inflammatory reactions after uterine artery embolization. The secondary purpose of this study it to investigate the effects of dexamethasone on postembolization syndrome (severe pain, nasea and vomiting).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 64
Inclusion Criteria
- Uterine artery embolization due to multiple myoma or adenomyosis
Exclusion Criteria
- Diabetic mellitus
- Steroid administration
- Liver or kidney dysfuntion
- High baseline CRP or leukocytosis (>11,000/μL )
- Drug allergy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group Normal saline - Dexamethasone group Dexamethasone -
- Primary Outcome Measures
Name Time Method Inflammatory reactions 24 hours CRP, WBC, neutrophil (%), cortisol : pre-UAE, post-UAE 12 h, post-UAE-24 h IL-6 : pre-UAE, post-UAE-24 h
- Secondary Outcome Measures
Name Time Method Pain 24 hours Immediately after UAE, post-UAE 1, 2, 4, 6, 8, 12, 24 h
Nausea and vomiting 24 hours Immediately after UAE, post-UAE 1, 2, 4, 6, 8, 12, 24 h
Sucessful rate at 3 month after UAE 3 month Utrerine volume and complete necrosis incidence
Trial Locations
- Locations (1)
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine
🇰🇷Seoul, Korea, Republic of