The efficacy of strength training combined with functional skills training on muscle structure and function in young adults with cerebral palsy.

Not Applicable

Completed

• Conditions: Cerebral palsy; Neurological - Other neurological disorders; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12614001217695
• Lead Sponsor: Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-11-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

a) Aged between 15 and 30 years
b) Have a confirmed diagnosis of spastic hemiplegia or diplegia type CP
c) Can walk independently
d) Are Gross Motor Function Classification System (GMFCS) levels I or II
e) Who have maximum passive ankle dorsiflexion range of motion of <5 degrees (knee fully extended).

Exclusion Criteria

a) Have had previous lower limb surgery in the last 2 years and/or Botulinum toxin-A injections to the lower extremities within the last 6 months
b) Cannot provide sufficient cooperation and cognitive understanding to participate in the intervention exercises
c) Have undertaken lower limb resistance training within the last 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gastrocnemii, Soleus (SOL), and Tibialis Anterior (TA) muscle volume as assessed by Magnetic Resonance Imaging (MRI)[All outcome measures will be taken at baseline (pre-training), immediately following training (12 weeks), and 12 weeks following the cessation of training (24 weeks).];Neuromechanical properties of the Medial Gastrocnemius (MG) muscle:<br>Passive and active mechanical properties of the MG muscle will be assessed using 2-dimensional B-mode ultrasound and a Biodex isokinetic dynamometer. Neural properties of the MG muscle will be measured using EMG data recorded from surface electrodes placed over the muscle bellies of the MG, Lateral Gastrocnemius (LG), SOL and TA. The level of voluntary activation of the MG muscle will be assessed using the interpolated twitch technique. <br><br><br>[All outcome measures will be taken at baseline (pre-training), immediately following training (12 weeks), and 12 weeks following the cessation of training (24 weeks).]