The effect of folate supplementation on Non Alcoholic Fatty Liver Disease treatment
- Conditions
- on alcoholic fatty liver.Fatty (change of) liver
- Registration Number
- IRCT2015051710333N2
- Lead Sponsor
- Ilam University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 40
Inclusion Criteria: Diagnosis to have non alcoholic fatty liver disease confirmed with ultrasonography result; ages above 18 ; serum alanine transaminase enzyme level higher than 30 U/L ; Diabetic patients will include if they have been recently diagnosed with diabetes and not using blood glucose lowering drugs or if they consume insulin and metformin, it would pass at least 6 months from starting the treatment and during this period the dose of metformin and insulin are not changed. Exclusion criteria: Alcohol consumption greater than 20 g per day; diseases such as hereditary hemochromatosis; Wilson's disease; an enzyme deficiency a1 Antitripsin; history of jejunoileal bypass surgery or gastroplasty; experience to perform the total parenteral nutrition at 6 months before; consomption of statins and hepatotoxic drugs such as calcium channel blocker; methotrexate; amiodarone; chloroquine; a history of hypothyroidism and Cushing's syndrome; Intake of folate; B12; vitamin E; omega-3 supplements during last 6 months.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum Alanine Transaminase. Timepoint: Before and after intervention. Method of measurement: U/L - Laboratory kit.;Grade of fatty liver based on ultrasonography results. Timepoint: Before and after intervention. Method of measurement: Ultrasonography scan.
- Secondary Outcome Measures
Name Time Method Serum Total cholestrol. Timepoint: Before and after intervention. Method of measurement: mg/dL - Laboratory kit.;Serum LDL-C. Timepoint: Before and after intervention. Method of measurement: mg/dL- laboratory kit.;Serum HDL-C. Timepoint: Before and after intervention. Method of measurement: mg/dL- laboratory kit.;Serum Homocystein. Timepoint: Before and after intervention. Method of measurement: Laboratory kit-umol/Liter.;Serum Triglyceride. Timepoint: Before and after intervention. Method of measurement: mg/dL- Laboratory kit.;Serum Aspartate Transaminase (AST). Timepoint: Before and after intervention. Method of measurement: U/L- laboratory kit.