Effect of high folic acid levels on enzymes activity and its relation withexpression of genes related to folate metabolism

Phase 4

Recruiting

• Conditions: healthy individuals; women with recurrent miscarriage; high doses of folic acid; D03.438.733.631.400; C13.703.039; M01.774.500

• Registration Number: RBR-5mr2zq
• Lead Sponsor: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-03-27
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

For the group of non-pregnant women with a history of primary miscarriage: women aged 18-40 years; at least two histories of recurrent spontaneous miscarriage; no viable fetus; in use of 5 mg of folic acid daily. For the prospective study with intervention of 5 mg of folic acid per day: healthy volunteers; both sexes, from 18 to 45 years, non smokers.

Exclusion Criteria

Women with a history of abortion who are pregnant during study enrollment. For the study with intervention of 5 mg of folic acid per day will be excluded chronic alcoholics; patients with chronic diseases; pregnant women; smokers; individuals who underwent major surgery to less than 6 months or donated blood in the last 3 months; and Those who have used polivitamins in the last 6 months.

Study & Design

• Study Type: Intervention
• Study Design: Not specified