The effect of ketone ester intake on the oral glucose tolerance test

Not Applicable

• Conditions: lifestyle-related disease

• Registration Number: JPRN-UMIN000037787
• Lead Sponsor: Sportology center, Juntendo University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-07-31
• Study Start: 2019-08-24
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

1, history of diabetes 2, history of food allergy 3, history of drug hypersensitivity 4, habitual drinker (ethanol=>30g/day) 5, history of hypertension or dyslipidemia 6, history of digestive system disease 7, history of digestive surgical operation 8, history of hepatitis B virus or hepatitis C virus 9, history of hepatitis heart disease 10, liver dysfunction (AST,ALT:=>51U/L, gamma-GTP=>101U/L) or renal dysfunction (urinary protein2+,uric blood2+,creatinine level=>1,3mg/dl) 11, Recent weight changes or attempts to lose weight (3kg weight gain or loss, within last 1 month) 12, low-carbohydrate diet (carbohydrate under 150g/day) 13, current smoker 14, subjects judged unsuitable to the study from staff (ex, for MRI)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The changes of blood glucose after ketone ester during oral glucose tolerance test (area under the curve)

Secondary Outcome Measures

Name	Time	Method
After ketone ester during oral glucose tolerance test - beta hydroxybutyrate - acetoacetic acid - total ketone - insulin - C-peptide - glucagon - free fatty acid - incretin hormone - Insulinogenic Index - Matsuda Index