Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- EEG Attention Lapse Measures on the Change Detection Task
研究概览
简要总结
The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. Our overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation.
This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •between ages of 18 and 50
- •ability to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks
- •ability to give valid informed consent
排除标准
- •no history of head trauma
- •no current or previous history of treatment with psychotropic medication
- •corrected vision 20/30 or better
- •tDCS/MRI contraindications, including: pregnancy, ferrous metal in any part of the body, serious medical conditions, claustrophobia, metallic implants, skin damage, conditions such as eczema at electrode sites, cranial pathologies
研究组 & 干预措施
DLPFC Stimulation
Intervention. 20 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex.
干预措施: Transcranial Direct Current Stimulation (Device)
Occipital Stimulation
Intervention. 20 minutes of 2 mA direct current stimulation over the occipital cortex.
干预措施: Transcranial Direct Current Stimulation (Device)
Sham Stimulation
Placebo Comparator. 0.5-1 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex followed by 19-19.5 minutes of sham stimulation
干预措施: Transcranial Direct Current Stimulation (Device)
结局指标
主要结局
EEG Attention Lapse Measures on the Change Detection Task
时间窗: Through study completion, an average of 1 month
Pre-trial power in the alpha frequency band (8-12 Hz)
EEG Attention Lapse Measures on the Stroop Task EEG Attention Lapse Measures on the Stroop Task
时间窗: Through study completion, an average of 1 month
Pre-trial power in the alpha frequency band (8-12 Hz)
Behavioral Attention Lapse Measures on the Change Detection Task
时间窗: Through study completion, an average of 1 month
Attention factor (a); Guess factor (g)
Behavioral Cognitive Control Measures on the Stroop Task
时间窗: Through study completion, an average of 1 month
Incongruent versus Congruent difference in error rate and reaction time
EEG Cognitive Control Measures on the Stroop Task
时间窗: Through study completion, an average of 1 month
response-locked power in the theta frequency band (4-7 Hz)
Behavioral Attention Lapse Measures on the Stroop Task
时间窗: Through study completion, an average of 1 month
Error Rate on Incorrect Congruent trials (Full Lapses) and Slow-but-Correct Congruent trials (Partial Lapses)
EEG Cognitive Control Measures on the Change Detection Task
时间窗: Through study completion, an average of 1 month
delay period power in the theta frequency band (4-7 Hz)
Delivered tDCS Dose to PFC
时间窗: Through study completion, an average of 1 month
Estimated electric field in PFC region of interest
Behavioral Cognitive Control Measures on the Change Detection Task Behavioral Cognitive Control Measures on the Change Detection Task
时间窗: Through study completion, an average of 1 month
WM storage capacity (k-max)
次要结局
未报告次要终点