CTRI/2024/03/063419尚未招募不适用
A single-centric, double-blinded randomized parallel group non-inferiority study to explore the synergistic effectiveness of perineural genicular nerve injection with 5% Dextrose in osteoarthritis knee receiving intra articular Platelet rich Plasma and Hyaluronic Acid.
未提供1 个研究点 分布在 1 个国家目标入组 52 人开始时间: 2024年3月15日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- The mean changes from baseline levels of knee pain using VAS
研究概览
简要总结
We postulate that the application of perineural genicular nerve blocks(GNB) by injecting 5% dextrose water will further augments the treatment effectiveness of PRP+HA offering long-lasting pain and functional improvements of the knee joints.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 50.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •patients willing to take part in the study and aged 50–80 years who presented with chronic knee pain, (i.e., knee pain of moderate or greater intensity on most or all days for ≥ 3 months) 2)Following radiological assessments, radiological tibiofemoral OA (Kellgren-Lawrence grade 2–4 as evaluated by a radiologist.
排除标准
- •acute knee pain, prior knee surgery, other connective tissue diseases that affected the knee, serious neurological or psychiatric disorders, steroid or hyaluronic acid injection therapy during the previous 3 months, sciatic pain, anticoagulant medication use and platelet count less than 1,50,000 per microliter.
结局指标
主要结局
The mean changes from baseline levels of knee pain using VAS
时间窗: 24hrs, 72hrs, 4, and 8 weeks
次要结局
- Functional changes in the knee (global perceived effect), patient satisfaction with treatment, changes in analgesics, the incidence of adverse effects, and the proportion of successful responders(24hrs, 72hrs, 4, and 8 weeks)
研究者
Subhamay Nanda
Daradia the pain clinic
研究点 (1)
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