Outcomes Following Tourniquet and Non-Tourniquet Assisted Total Knee Arthroplasty
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Osteoarthritis
- Sponsor
- University of Colorado, Denver
- Enrollment
- 28
- Locations
- 2
- Primary Endpoint
- Change from baseline in Quadriceps Muscle Force
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The overall goal of this study is to determine the effects of intraoperative tourniquet use during total knee arthroplasty (TKA), compared to TKA without the use of a tourniquet (NOTQT), for strength and functional recovery following simultaneous bilateral TKA. During the procedure, each patient will receive tourniquet-assisted TKA (TQT) on one lower extremity while the contralateral lower extremity undergoes TKA without the use of a tourniquet (NOTQT), except for briefly during component cementation. Tourniquets are commonly used in TKA to improve visualization of the surgical field and limit blood loss. However, studies suggest that tourniquet use may be associated with higher rates of medical complications and poor functional outcomes, including increased swelling, decreased muscle strength and altered neuromuscular activity. We will measure strength, voluntary muscle activation, and other functional outcomes for each lower extremity at 4 time points (preop; inpatient (24-72 hrs after surgery); 3 weeks; and 3 months following TKA). We hypothesize that lower extremities in the NOTQT group will demonstrate improved strength and performance when compared to lower extremities in the TQT group.
Investigators
Eligibility Criteria
Inclusion Criteria
- •undergoing primary, simultaneous bilateral knee arthroplasty for osteoarthritis
Exclusion Criteria
- •no neurological, vascular or cardiac problems that limit function or any unstable orthopaedic conditions that limit functional performance
Outcomes
Primary Outcomes
Change from baseline in Quadriceps Muscle Force
Time Frame: Pre-operative, 3 weeks and 3 months post-operative
NOTQT will result in greater quadriceps muscle strength (primary outcome) after TKA, compared to TQT group. Benefits will be apparent at 48-72 hrs and 3 weeks (primary endpoint), and persist though 3 months following TKA
Secondary Outcomes
- Change from Baseline in Isometric Hamstring Strength(Pre-operatively, 3 weeks and 3 months post-operative)
- Change from Baseline from Voluntary Quadriceps Activation(Pre-operative, 3 weeks and 3 months post-operative)
- Change from Baseline in Balance testing(Pre-operatively, 3 weeks and 3 months post-operative)
- Change from Baseline in Range of Motion(Pre-operatively, 3 weeks and 3 months post-operatively)