Endothelial Glycocalyx Damage in Brain Death Organ Donors

Active, not recruiting

• Conditions: Brain Damage Due to Hypoxia; Organ Donors; Organ Transplant Failure or Rejection
• Interventions: Diagnostic Test: Endothelial glycocalyx damage assessment

• Registration Number: NCT05609123
• Lead Sponsor: University Hospital Hradec Kralove

Brief Summary

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-01
• Study First Submitted: 2022-10-29
• Study First Submitted QC: 2022-11-05
• Study First Posted: 2022-11-08
• Primary Completion: 2024-12-31
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-24
• Last Update Posted: 2025-03-27
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patients in critical condition declared as brain dead by clinical examination

Exclusion Criteria

• N/A

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Brain dead organ donors	Endothelial glycocalyx damage assessment	Patients with clinically proven bain death were assigned to the paraclinical confirmatory investigation of the brain death and subsequently accepted into the transplantation program.

Primary Outcome Measures

Name	Time	Method
Markers of endothelial glycocalyx damage	baseline at the time of inclusion	Levels of syndecan-1 in serum and urine

Trial Locations

Locations (1)

University Hospital Hradec Kralove; 🇨🇿 Hradec Kralove, Czechia