Colistin Versus Colistin Plus Fosfomycin for Infections Caused by MDR Acinetobacter Baumannii
- Registration Number
- NCT01297894
- Lead Sponsor
- Mahidol University
- Brief Summary
In Siriraj Hospital, colistin alone for treatment of MDR A. baumannii contributed to mortality 45% Fosfomycin is an antimicrobial which has activity against gram-negative bacterial including MDR A. baumannii In this study, we compare the clinical and microbiologicalresponse of colistin alone versus colistin plus fosfomycin in treatment of A. baumannii infected patients
- Detailed Description
Inclusion criteria
* Age\> 18 years
* Hospitalized to Siriraj Hospital
* Infected caused by A. baumannii
* Need Colistin treatment
Exclusion criteria
* Pregnancy or Lactating mother
* Colistin or Fosfomycin Allergy
* Patients who have severe abnormal renal or liver function
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 92
- Age> 18 years
- Hospitalized to Siriraj Hospital
- Infected caused by A. baumannii
- Need Colistin treatment
Exclusion criteria:
- Pregnancy or Lactating mother
- Colistin or Fosfomycin Allergy
- Patients who have severe abnormal renal or liver function
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description colistin plus fosfomycin colistin plus fosfomycin colistimethate sodium 2.5-5mg/kg iv plus fosfomycin 2gm iv every 12 hours colistin colistin Colistimethate sodium 2.5-5mg/kg iv
- Primary Outcome Measures
Name Time Method number of subjects with cure or improvement up to 28days cure improvement worse death
- Secondary Outcome Measures
Name Time Method number of subjects with eradication of causative bacteria up to 28days eradication persistence superinfection
Trial Locations
- Locations (1)
Siriraj Hospital
🇹🇭Bangkok, Thailand