Colistin Plus Fosfomycin in Multi-Drug Resistant Acinetobacter Baumannii
试验速览
- 阶段
- 3 期
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- number of subjects with cure or improvement
研究概览
简要总结
In Siriraj Hospital, colistin alone for treatment of MDR A. baumannii contributed to mortality 45% Fosfomycin is an antimicrobial which has activity against gram-negative bacterial including MDR A. baumannii In this study, we compare the clinical and microbiologicalresponse of colistin alone versus colistin plus fosfomycin in treatment of A. baumannii infected patients
详细描述
Inclusion criteria
- Age> 18 years
- Hospitalized to Siriraj Hospital
- Infected caused by A. baumannii
- Need Colistin treatment
Exclusion criteria
- Pregnancy or Lactating mother
- Colistin or Fosfomycin Allergy
- Patients who have severe abnormal renal or liver function
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age> 18 years
- •Hospitalized to Siriraj Hospital
- •Infected caused by A. baumannii
- •Need Colistin treatment
- •Exclusion criteria:
- •Pregnancy or Lactating mother
- •Colistin or Fosfomycin Allergy
- •Patients who have severe abnormal renal or liver function
排除标准
- 未提供
研究组 & 干预措施
colistin
Colistimethate sodium 2.5-5mg/kg iv
干预措施: colistin (Drug)
colistin plus fosfomycin
colistimethate sodium 2.5-5mg/kg iv plus fosfomycin 2gm iv every 12 hours
干预措施: colistin plus fosfomycin (Drug)
结局指标
主要结局
number of subjects with cure or improvement
时间窗: up to 28days
cure improvement worse death
次要结局
- number of subjects with eradication of causative bacteria(up to 28days)
研究者
Visanu Thamlikitkul
Division of Infectious Diseases and tropical medicine, Department of medicine, Faculty of Medicine Siriraj Hospital.
Mahidol University