Brain development, brain functioning, growth and metabolic aspects in the clinical management of transsexual adolescents

Not Applicable

Completed

• Conditions: Transsexuality; Mental and Behavioural Disorders

• Registration Number: ISRCTN81574253
• Lead Sponsor: Vrije University Medical Centre (VUMC) (The Netherlands)

Brief Summary

Abstract results in http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17074986 2017 Results article in https://pubmed.ncbi.nlm.nih.gov/28419243/ (added 06/08/2021) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32909025/ (added 06/08/2021) 2013 Results article in https://pubmed.ncbi.nlm.nih.gov/23433223/ (added 06/08/2021) 2015 Results article in https://pubmed.ncbi.nlm.nih.gov/25720349/ (added 06/08/2021) 2016 Results article in https://pubmed.ncbi.nlm.nih.gov/27318023/ (added 06/08/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-05-02
• Study Completion: 2009-12-31
• Last Update Posted: 17 August 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 264

Inclusion Criteria

Inclusion criteria - pubertal patients:
1. Girls and boys with transsexualism who are eligible for sex reassignment according to psychologist and psychiatrist (if they are older than 12 years, psychologically stable and live in a stable social environment)
2. Girls have to be in stage B2 and boys in G2-G3 with measurable oestradiol and testosterone levels respectively

Inclusion criteria - pre-pubertal patients:
1. Girls and boys with high probability of transsexualism according to psychologist or psychiatrist and the age of 9 to 12 years
2. Girls have to be in an earlier stage than B2 and boys in an earlier stage than G2-G3

Inclusion criteria - healthy subjects:
1. Girls and boys who are similar aged friends of the transsexual patients

Exclusion Criteria

Exclusion criteria - patients:
1. Intersex conditions

Exclusion criteria - healthy subjects:
1. Puberty delaying treatment or hormonal therapy; oral anticonception users are not excluded

Study & Design

• Study Type: Observational
• Study Design: Not specified