Vasopressor Preload Modulation During General Anaesthesia

• Conditions: Anesthesia

• Registration Number: NCT05193097
• Lead Sponsor: Jakob Højlund

Brief Summary

Is is debated whether administration of pure vasopressor may augment cardiac output (CO) by means of preload modulation. We wish to test this in 20 patients under general anesthesia, with preload dependency induced by head-up-tilt and preload modulation with infusion of phenylephrine. To document any changes in CO the patients will be monitored by Lithium dilution method. Furthermore we will monitor changes in peripheral perfusion index and test the ability of this non-invasive modality to track changes in CO.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-12
• Study First Submitted: 2021-12-31
• Study First Submitted QC: 2021-12-31
• Last Update Submitted: 2021-12-31
• Study Start: 2022-01-03
• Study First Posted: 2022-01-14
• Last Update Posted: 2022-01-14
• Primary Completion: 2023-03-31
• Study Completion: 2023-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Planned surgery under general anesthesia

Exclusion Criteria

• atrial fibrillation
• refusal to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in cardiac output	30 minutes
Changes in peripheral perfusion index	30 minutes