Effect of Variance on Error Correction During Coupling (Cerrebellar Lesions)
- Conditions
- Cerebellar Lesions
- Interventions
- Other: Synchronisation abilities
- Registration Number
- NCT04887753
- Lead Sponsor
- Hasselt University
- Brief Summary
This study is a case-control study, involving persons with persons with cerebellar lesions and healthy controls. The study contains 1 descriptive and 3 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, with period and phase auditory manipulations. In the latter twp sessions, apart from outcome measures of synchronization the following will be collected as well: brain activity using EEG recordings, spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 80
- diagnosis of cerrebellar lesions
- walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted)
- cognitive impairment impeding understanding of
- instructions,
- beat amusia,
- deafness,
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description persons with cerebellar lesions Synchronisation abilities - Healthy controls Synchronisation abilities -
- Primary Outcome Measures
Name Time Method Scale for the assessment and rating of ataxia baseline ataxia
6 minute walking test baseline gait pattern and endurance
cerebellar affective syndrome test baseline cognitive test
Motricity Index of dorsi flexors, knee extensors and hip flexors baseline Muscle weakness
Perceptual tempo and rhythm judgements week 1 subjective indications in regards to what the participants hear in terms
Activities-specific balance confidence scale baseline rating of balance confidence in performing activities of daily life
64 channel EEG measurement week 1 neural correlates of entrainment
Asynchrony week 1 timing difference between the tap and the beat
Time up and Go test baseline Balance
Dual task questionnaire baseline troubles a person have when performing a dual task during daily activity
Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts baseline Spasticity
Dynamic gait index baseline dynamic balance
Modified fatigue impact scale baseline effect of fatigue
Hospital Anxiety and Depression Scale baseline determine the levels of anxiety and depression
Relative phase angle week 3 asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)
Resultant Vector Length week 3 synchronisation consistency
- Secondary Outcome Measures
Name Time Method Speed week 3 gait velocity (m/s)
Cadencce week 3 number of steps per minute
Stride length week 3 distance between consecutive steps (cm)
Double Support week 3 time that both legs are in contact with the floor (mseconds)
Perceived motivation week 3 A Likert scale will be used, and participants will be asked to rate their perceived motivation of walking after each experimental walking conditions
Perceived cognitive and physical fatigue week 3 A visual analogue scale will be used, and participants will be asked to rate their perceived cognitive and physical fatigue levels before and after each experimental walking conditions
Perceived walking speed week 3 A Likert scale will be used, and participants will be asked to rate their perceived walking speed relative to their usual walking after each experimental walking conditions
64 channel EEG measurement (only conducted in 4 PwMS and HC) week 3 Neural correlates of entrainment
Trial Locations
- Locations (1)
Hôpital Civil Marie Curie
🇧🇪Lodelinsart, Belgium