Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Number of skin conductance fluctuations
研究概览
简要总结
24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.
详细描述
Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.
Study hypothesis: SC is not influenced by i.v. administration of atropine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients in ASA-group 1-2
- •Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour
- •informed consent
排除标准
- •Patients using any medication known to influence the autonomous nervous system
- •Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)
- •Pregnancy
结局指标
主要结局
Number of skin conductance fluctuations
次要结局
未报告次要终点