Effect of folic acid in Buerger`s disease
- Conditions
- Buerger`s disease.Thromboangiitis obliterans [Buerger]
- Registration Number
- IRCT201108012106N2
- Lead Sponsor
- Applied Physiology Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 30
Buerger`s patients referring to Alzahra hospital who have consent of participation to study; history of smoking; onset of disease before 50 year-old; upper limb involvement or phlebitis migrants; obliterative arterial disease below popliteal artery and no risk factor of atherosclerosis except smoking; no history of hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular disease or collagen vascular disease.
Exclusion criteria: surgical (sympathectomy or vascular bypass) or medical (Illeoprost or corticosteroid) changes in treatment; starting Aspirin, calcium channel blocker, VitB6 or VitB12 or stop smoking during the study; drug incompliance during the study and not willing to continue the study.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Scale of wound. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Wagner Scale.
- Secondary Outcome Measures
Name Time Method Homocysteine. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Lab test.;Scale of pain. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: VAS.;Anticardiolipin. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Lab test.;Size of wound. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Millimeter.;Number of steps walkingwithout pain. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Number.;Sense of patient about healing. Timepoint: At the 2nd and 6th months. Method of measurement: Ask a patient.;Minor amputation. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Number.;Major amputation. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Number.