Efficacy and Safety of Platelet-Rich Plasma As an Intraoperative Holding Solution in Hair Transplantation

Not Applicable

Completed

• Conditions: Hair Transplantation
• Interventions: Other: Saline; Biological: Platelet rich plasma (PRP)

• Registration Number: NCT06849674
• Lead Sponsor: Benha University

Brief Summary

The goal of this study is to determine the efficacy of using platelet-rich plasma (PRP) versus 0.9% normal saline as a storage solution during follicular unit extraction (FUE) hair transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-23
• Primary Completion: 2024-11-28
• Study Completion: 2024-11-28
• Status Verified: 2025-02
• Study First Submitted: 2025-02-19
• Study First Submitted QC: 2025-02-23
• Last Update Submitted: 2025-02-26
• Study First Posted: 2025-02-27
• Last Update Posted: 2025-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Male patients who have androgenetic alopecia
• Patients who are interested in having their hair transplanted

Exclusion Criteria

• Individuals with comorbidities
• History of keloids or hypertrophic scarring
• Low donor area density
• Other causes of alopecia
• Scalp infections
• Patients with a bleeding tendency
• Patients on anticoagulant therapy
• Patients who are HIV-positive or Hepatitis B- or C-positive

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline group	Saline	in this group, hair grafts will be stored in Normal saline 0.9% before transplantation.
Platelet-rich plasma group	Platelet rich plasma (PRP)	In this group, hair grafts will be stored in Platelet-rich plasma before transplantation.

Primary Outcome Measures

Name	Time	Method
Change in Hair density	12 weeks after hair transplantation	Hair density (the number of hairs per square centimeter) will be measured using a trichoscope and digital photography in the recipient area.
Percentage of Hair Growth	12 weeks after hair transplantation	The percentage of graft survival will be assessed by comparing the number of transplanted hairs to the number of hairs that have grown in the recipient area using trichoscopic analysis and digital photography. The formula used will be: (number of grown hairs/number of transplanted hairs) x100%

Secondary Outcome Measures

Name	Time	Method
Incidence of Postoperative complications	within 1 month after hair transplantation	The number and type of complications, including infection,graft necrosis, excessive shedding, and scalp irritation, will be documented. The severity of complications will be assessed using clinical examination and patient reports
Patient satisfaction score	12weeks after hair translantation	Patient satisfaction will be assessed using Likert scale from 1 to 5 regarding aesthetic results, hair density, and natural appearance. Higher scores indicate greater satisfaction.

Trial Locations

Locations (1)

Dermatology, Venereology and Andrology Faculty of Medicine- Benha University; 🇪🇬 Benha, Qalyubia, Egypt