Influence of Silicone Hydrogel Extended Contact Lens Wear on Corneal Sensitivity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- difference in corneal sensitivity threshold baseline and after 7 days of extended contact lens wear
研究概览
简要总结
Soft contact lens wear reduces the amount of oxygen reaching the eye, which may have an influence on corneal sensitivity. The aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline and after 6 days of continuous, extended contact lens wear.
详细描述
Contact lens wear may have an influence on corneal sensitivity, by three mechanisms: hypoxic, mechanical and inflammatory. Extended silicone hydrogel contact lens wear increases the risk of infections. A change in corneal sensitivity may be considered as an indicator for change in corneal physiology. It is there the aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline and after 6 days of continuous, extended contact lens wear.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •no contact lens wear three days before first visit
- •corneal radius between 7.4 and 8.0; if corneal radius >8.0, corneal diameter must be at least 12 mm; if corneal radius < 7.4, corneal diameter must be < 12.0
- •OSDI score no higher than 13 points
排除标准
- •systemic disease that may have an influence ocular healtjh
- •active ocular disease and no history of ocular surgery
结局指标
主要结局
difference in corneal sensitivity threshold baseline and after 7 days of extended contact lens wear
时间窗: 7+/-1 days
The difference in corneal sensitivity threshold baseline versus after 7 days of extended contact lens wear will be determined. Corneal sensitivity measurement will take place with the Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) and will be recorded in mbar.
次要结局
- correlation between corneal sensitvity threshold and subjective symptoms(7+/-1 days)
研究者
Daniela Nosch
Clinical Professor
University of Applied Sciences and Arts Northwestern Switzerland